Portal Biotech

What Portal Biotech does

Portal Biotech is developing the first platform capable of sequencing entire proteins at the single-molecule level, replacing fragmented views with a complete picture. Leveraging machine-learning algorithms and nanopore technology, their platform delivers rapid, real-time information on protein identity, abundance, and structure. This technology aims to empower scientists to understand proteins in depth and in real time, enabling faster drug discovery, more accurate diagnostics, and stronger pandemic readiness. The company offers bench-top solutions for comprehensive single-molecule protein sequencing and characterisation, available through their protein characterisation services and an Early Access Programme.

Products

• Small-molecule DXDetects and quantitates small-molecules and metabolites, and assesses sample purity.
• Peptide spectrometry (NPS)Quantitates peptides and their post-translational modifications using a mass-spec compatible workflow, with sensitivity to charge, shape, and volume for discriminating chirality and other isobaric changes.
• Full-length protein sequencingAnalyzes intact proteins from end-to-end, identifying the protein and the location of any modifications on a single molecule basis.
• Bench-top instrumentsA range of bench-top instruments that bring state-of-the-art protein characterisation to the lab.

Key capabilities

• Single-molecule protein sequencing
• Nanopore technology
• Machine learning algorithms for decoding electrical signatures
• Rapid workflows
• Real-time results
• Flexible assays for any proteomic or metabolomic analysis
• Full-length protein analysis (intact single molecules or peptide fragments)
• Accessible cost-effective bench-top technology
• Scalable for low- and high-volume labs
• Quantitative analysis by counting molecules

Use cases

• Understanding the proteome
• Faster drug discovery
• More accurate diagnostics
• Stronger pandemic readiness
• Detecting and quantitating small-molecules and metabolites
• Assessing sample purity
• Quantitating peptides and their post-translational modifications
• Analyzing intact proteins from end-to-end
• Identifying protein mutations and modifications
• Quantitation of proteins
• Assessing protein synthesis, degradation, and impurities
• Characterizing post-translational modifications (phosphorylation, glycosylation, acetylation, deamidation, conjugation, proteolysis)

AI approach

Portal Biotech leverages machine learning algorithms coupled with nanopore technology to decode electrical signatures from molecules, revealing identity and detailed sequence information. This is applied to single-molecule proteomics for protein sequencing and characterisation.

Tech named: machine-learning algorithms, nanopore technology

Industries served

• Biotechnology
• Biopharmaceutical
• Academic research
• Industrial

What it says sets it apart

• First platform capable of sequencing entire proteins at the single-molecule level
• Replaces fragmented views with a complete picture of proteins
• Leverages pioneering work from the Maglia Lab at the University of Groningen
• Uses nanopores as exquisite biosensors to detect and analyze single molecules with unparalleled sensitivity
• Couples nanopore platform to state-of-the-art machine learning algorithms to decode electrical signatures
• Unique and versatile chemistry allows proteins to be read from end-to-end as intact single molecules or as peptide fragments
• Provides complete coverage of the protein, its sequence, and all its modifications in context

Funding rounds we track

From the AI funding tracker — rounds as reported by the linked publications.