Boltz

What Boltz does

Boltz PBC is a frontier research lab building powerful new models and infrastructure for scientific discovery in biology and chemistry. They develop foundational AI models and high-performance compute for designing all of life's molecules, including small molecules and proteins. Their platform offers end-to-end molecular design and discovery, with features like blazing-fast inference, secure deployment options (multi-tenant, single-tenant, on-premise), and fine-tuning capabilities for proprietary data. Boltz aims to advance the open frontier of biomolecular AI and make powerful AI tools accessible to scientists, integrating with existing tools and supporting agentic science.

Products

• Boltz APIAn enterprise-grade REST API with built-in security and data privacy for integrating Boltz models and high-performance compute into agentic products or pipelines. It provides new primitives for molecular biology and supports de novo protein design, small-molecule design, and screening.
• BoltzMol-1An experimentally validated generative model for small-molecule work, including hit discovery with a configurable, synthesis-aware generative model.
• BoltzProt-1An experimentally validated generative model for protein design, including de novo design and optimization across peptides, antibodies, and nanobodies.
• Boltz LabA platform offering access to Boltz models and agents, with options for professional subscriptions and enterprise solutions. It includes a sandbox for research.
• Small-molecule pipelineA pipeline for small-molecule design and screening, available through the Boltz API and Boltz Lab.
• Protein design pipelineA pipeline for protein design and screening, available through the Boltz API and Boltz Lab.

Key capabilities

• Foundational AI for Biology and Chemistry
• Frontier models for biomolecular modeling and design
• High-performance compute
• Blazing-fast inference (thousands of proteins and small molecules in minutes)
• Secure deployment (Multi-tenant, Single-tenant, On-premise)
• SOC 2 Type 1 verified
• Fine-tuning models with proprietary data, targets, and assays
• Integration with existing scientific tools
• Agentic science primitives
• Usage-based pricing
• IP & Ownership: Customers own everything they create
• Data Security: Customer data remains secure, confidential, and not used for model training
• Massively parallel cluster for running jobs
• Deploy in VPC or fully on-premise for data residency control
• Enterprise-grade REST APIs

Use cases

• Small-molecule screening and hit discovery
• Biomolecular modeling and design
• De novo protein design
• Optimization of peptides, antibodies, and nanobodies
• Integrating state-of-the-art biomolecular models into agentic products or pipelines
• Accelerating drug discovery
• Testing hypotheses in silico before committing reagents
• Designing bispecific antibodies
• Fine-tuning binding-affinity predictors for medicinal-chemistry campaigns
• Selecting compounds for synthesis
• Structure & binding prediction
• ADME prediction

AI approach

Boltz builds foundational AI models for biomolecular modeling and design, specifically for biology and chemistry. They offer frontier models and high-performance compute for designing molecules, with applications in small-molecule screening, hit discovery, and protein design. They also provide an API for integrating these models into agentic products and pipelines, and allow fine-tuning of models with proprietary data.

Tech named: BoltzMol-1, BoltzProt-1, Boltz API, Claude Science, Anthropic's new AI workbench, Claude Opus 4.6, Claude Code, LLMs

Industries served

• Biopharma
• Agriculture
• Consumer products
• Academia
• Biotechnology Research

What it says sets it apart

• Foundational AI models for biology and chemistry
• Experimentally validated models (BoltzMol-1, BoltzProt-1)
• Blazing-fast inference speeds (minutes vs. days)
• Flexible deployment options (multi-tenant, single-tenant, on-premise)
• SOC 2 Type 1 verified security
• Customer data ownership and non-use for model training
• Integration with leading life science and AI agent companies
• Focus on removing both reasoning and execution bottlenecks in scientific discovery
• Agent-driven API for autonomous scientific tasks